Best Doctor-Prescribed Weight Loss Medications in 2025

Singapore faces a growing challenge with weight management, as nearly 40% of adults are overweight or obese. For many, medications approved by doctors provide effective support for long-term weight loss. The top options in 2025 include Semaglutide, Tirzepatide, and Liraglutide, each offering unique benefits for managing weight and improving metabolic health. Here's a quick summary:

• Semaglutide: Weekly injections or daily tablets that help reduce appetite and improve blood sugar control. Average weight loss: up to 15.8% over 68 weeks. Monthly costs: S$350–S$500.
• Tirzepatide: A once-weekly injection targeting two hormone receptors for enhanced results. Average weight loss: up to 22.5% over 72 weeks. Monthly costs: from S$479.60.
• Liraglutide: A daily injection for gradual weight loss, also beneficial for heart health in diabetes patients. Average weight loss: about 6% over 56 weeks. Monthly costs vary.

These medications are available via telehealth platforms in Singapore, starting at S$350 per month, with convenient delivery and ongoing doctor support. Pairing them with a healthy diet and regular exercise is essential for the best outcomes.

Quick Comparison:

Speak to a doctor to determine the most suitable option based on your health needs and goals.

1. Semaglutide

Mechanism and Efficacy

Semaglutide belongs to a class of medications called GLP-1 receptor agonists. It works by mimicking a natural hormone released in the gut after eating, which helps regulate blood sugar and appetite. Thanks to its structural tweaks, semaglutide resists breakdown, allowing it to remain active longer. It stimulates insulin release when blood sugar levels rise, slows the rate at which the stomach empties, and enhances feelings of fullness while curbing cravings.

Clinical trials of high-dose semaglutide (marketed as Wegovy) have shown promising results. About 39% of participants lost more than 20% of their body weight within two years, with an average weight reduction of up to 15.8% over 68 weeks. Dr Andrew, a Family Physician at Doctor Anywhere, shared his perspective:

"GLP-1 medications have provided significant advancement in our approach to managing diabetes and weight-related issues. They offer multiple benefits including blood sugar control and appetite regulation."

Safety Profile

While semaglutide is generally well-tolerated, it can cause gastrointestinal side effects such as nausea, vomiting, diarrhoea, or constipation, which typically subside as the body adjusts. However, there are rare but serious risks, including pancreatitis, gallbladder problems, kidney issues, and thyroid-related concerns. This medication is not suitable for individuals who are pregnant, breastfeeding, planning to conceive, or those with a history of thyroid cancer or pancreatitis. Close medical supervision is crucial to monitor for potential risks and to fine-tune the dosage as needed.

Practical Use in Singapore

In Singapore, semaglutide is available in three forms: Ozempic (a weekly injection for type 2 diabetes), Wegovy (a weekly injection for long-term weight management, also approved for adolescents aged 12 and above), and Rybelsus (a daily oral tablet). The typical treatment starts at a weekly dose of 0.25 mg, gradually increasing every four weeks to a maintenance dose of 2.4 mg.

The cost of injectable Wegovy ranges between S$350 and S$500 per month, while oral Rybelsus is priced between S$180 and S$400 monthly. MOH-approved telehealth platforms in Singapore provide personalised consultations, convenient doorstep delivery, and unlimited follow-ups to support patients using semaglutide. To maximise its effectiveness, semaglutide should be paired with a balanced, calorie-controlled diet and regular exercise.

Next, we’ll take a closer look at tirzepatide and its role in weight management.

2. Tirzepatide

Mechanism and Efficacy

Tirzepatide works by targeting both GIP and GLP-1 receptors, offering a dual-action approach to managing weight and improving metabolic health. This mechanism boosts insulin secretion from pancreatic beta cells, reduces glucagon release, and slows gastric emptying by 4–6 hours. These effects help regulate appetite and enhance insulin sensitivity.

Clinical trials, such as the SURMOUNT-1 study conducted over 176 weeks, revealed impressive results. Participants experienced average body weight reductions of –12.3%, –18.7%, and –19.7% for the 5-mg, 10-mg, and 15-mg doses, respectively, compared to just –1.3% for the placebo group. A separate review involving 5,800 patients found that 78.22% achieved at least 5% weight loss, 55.60% achieved 10% or more, and 32.28% lost at least 15% of their body weight. Beyond shedding kilos, tirzepatide also improved metabolic markers, reducing triglycerides by 15–20%, LDL cholesterol by 5–10%, and systolic blood pressure by 5–7 mmHg. These findings highlight its potential as a practical treatment option in Singapore.

Safety Profile

Tirzepatide shares common side effects with other GLP-1 medications, including gastrointestinal discomfort such as nausea, vomiting, diarrhoea, constipation, and stomach pain. Other side effects may include fatigue, headaches, and mild injection site reactions. These issues are generally mild to moderate and often occur during the initial dose-escalation phase. However, rare but serious risks include pancreatitis, gallbladder issues, kidney problems, low blood sugar (especially when combined with other diabetes medications), and thyroid-related concerns. Because of these risks, tirzepatide is not suitable for individuals who are pregnant, breastfeeding, or have a history of thyroid cancer or pancreatitis. Regular medical supervision is crucial to monitor for any unusual symptoms during treatment.

Practical Use in Singapore

In Singapore, tirzepatide is sold under the brand name Mounjaro® and is available as a prescription-only, once-weekly injection. Dosages range from 2.5 mg to 15 mg. Treatment typically starts at 2.5 mg per week for the first four weeks to minimise gastrointestinal side effects, with gradual increases thereafter. To avoid lipodystrophy, injection sites should be rotated among the abdomen, thigh, and upper arm. With a half-life of five days, the once-weekly dosing is both convenient and effective.

Prices begin at S$479.60 per monthly dose, with costs varying based on the prescribed strength. MOH-approved telehealth platforms in Singapore offer consultations, medication delivery, and follow-up care. For storage, tirzepatide should be refrigerated at 2–8°C until its first use. Once opened, it remains stable at room temperature (up to 30°C) for up to 21 days. For the best results, tirzepatide should be paired with a balanced diet and regular exercise.

3. Liraglutide

Mechanism and Efficacy

Liraglutide works by activating GLP-1 receptors, which help reduce appetite, slow down gastric emptying, and stabilise blood sugar levels. Essentially, it signals the brain that the body is full, making portion control and calorie reduction more manageable.

Clinical studies report an average weight loss of 6% over 56 weeks. While this may seem modest compared to newer medications, it offers a steady and reliable option for those aiming for gradual weight management. Additionally, liraglutide has been shown to lower the risk of heart failure and major cardiovascular events in patients with type 2 diabetes. In Singapore, it is approved for adults with obesity (BMI ≥ 30 kg/m²) or those who are overweight (BMI ≥ 27 kg/m²) with at least one weight-related health condition. It is also approved for adolescents aged 12 to 17 years with obesity and a body weight over 60 kg. These benefits come with manageable side effects, which are discussed below.

Safety Profile

The most common side effects include mild gastrointestinal issues such as nausea, bloating, diarrhoea, constipation, vomiting, indigestion, and heartburn, most of which tend to improve over time. Other possible side effects include fatigue, headaches, and injection site reactions like redness, swelling, or itching.

Although rare, serious risks include pancreatitis, gallbladder problems, kidney issues, low blood sugar (especially when combined with insulin or sulfonylureas), allergic reactions, mood changes, and potential thyroid-related concerns. Liraglutide is not recommended for individuals with a personal or family history of medullary thyroid carcinoma or Multiple Endocrine Neoplasia syndrome type 2. It is also contraindicated for those who are pregnant, breastfeeding, or have severe gastrointestinal conditions or a history of pancreatitis. Regular medical supervision is crucial to monitor progress and address any side effects.

Practical Use in Singapore

In Singapore, liraglutide offers a flexible treatment option tailored to individual needs. It is a prescription-only, daily injectable medication. Unlike weekly injectables like semaglutide or tirzepatide, liraglutide requires daily morning injections. This allows for gradual dose adjustments, making it a suitable choice for patients who may benefit from a more personalised approach. However, its shorter duration of action compared to weekly alternatives means consistent daily use is essential.

Liraglutide is prescribed through licensed clinics following a thorough medical assessment to ensure it aligns with the patient’s health goals and overall condition. Approved clinics in Singapore, including those offering telehealth consultations, provide convenient access to liraglutide, along with efficient medication delivery services. For the best results, liraglutide should be combined with a balanced, low-calorie diet and regular physical activity.

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GLP-1 Medications for Weight Loss – FAQs Answered by a Primary Care Provider

Pros and Cons

Deciding on the right weight loss medication depends on your health objectives, lifestyle, and budget, as each option comes with its own set of advantages and challenges. Here's a quick comparison of the key benefits and limitations of each medication.

Tirzepatide has shown impressive results, with clinical trials indicating up to 22.5% weight loss over 72 weeks, and 36.2% of participants achieving at least 25% weight loss. The convenience of a once-weekly injection is a major plus. However, it tends to be more expensive and may cause noticeable gastrointestinal side effects, especially at the start.

Semaglutide offers a middle ground in terms of effectiveness and flexibility. Injectable versions have demonstrated up to 15.8% weight loss over 68 weeks, while the oral variant, Rybelsus, provides a needle-free option. It also delivers significant cardiovascular benefits, such as lowering the risk of heart attack, stroke, and kidney disease progression. That said, global supply shortages mean availability might only stabilise by mid-2025 or 2026.

Liraglutide achieves up to 6% weight loss over 56 weeks. Delivered through daily injections, it allows for personalised dose adjustments but requires more commitment compared to weekly alternatives. It has a well-established safety record and is particularly beneficial for type 2 diabetes patients at high cardiovascular risk.

It’s worth noting that none of these medications are covered by standard health insurance in Singapore and should always be used alongside a healthy diet and regular exercise.

Conclusion

The ideal weight loss medication depends on your individual health profile, lifestyle, and objectives. Tirzepatide delivers the most pronounced weight reduction, Semaglutide provides both injectable and oral options, while Liraglutide is a good choice for those seeking gradual, steady progress.

With over 1 in 10 Singaporeans classified as obese, finding effective treatments is crucial. Generally, eligibility for these medications requires a BMI of ≥30 kg/m² - or ≥27 kg/m² if there are related health conditions. For Asian populations, the threshold is slightly lower at ≥27.5 kg/m².

A consultation with a doctor is key to creating a personalised weight management plan. Medical professionals take into account your health history, current medications, and specific goals to recommend the most appropriate treatment. They also provide ongoing support to monitor your progress and address any side effects. With telehealth services, accessing this professional guidance has never been more convenient.

Trimly, an MOH-approved telehealth clinic, offers doctor-led consultations, tailored treatment plans, and unlimited follow-ups - all from the comfort of your home. Starting at S$350+ per month, you can access GLP-1 medications, including oral and injectable options, delivered right to your doorstep. This approach ensures safe, evidence-based weight loss support without needing to visit a clinic in person.

For the best results, combine these medications with a balanced, reduced-calorie diet and regular exercise. Always follow your doctor’s advice and avoid adjusting or stopping your medication without consulting them first.

FAQs

How do Semaglutide, Tirzepatide, and Liraglutide differ in their effects and usage?

Semaglutide, Tirzepatide, and Liraglutide are prescription medications designed to support weight loss, each with a slightly different approach. Semaglutide - sold under names like Wegovy, Ozempic, and Rybelsus - works by activating GLP-1 receptors, helping to control appetite and blood sugar levels. Wegovy and Ozempic are injectable, while Rybelsus is available as an oral tablet.

Tirzepatide takes it a step further by targeting both GLP-1 and GIP receptors, which may increase its effectiveness for weight loss. However, it is currently only offered as an injectable.

Liraglutide, marketed as Saxenda, is another injectable option that activates GLP-1 receptors. Unlike Semaglutide and Tirzepatide, which are administered weekly, Liraglutide requires daily injections.

The best choice depends on your weight loss goals, medical history, and how these medications fit into your lifestyle. Always consult your doctor to find the option that works best for you.

What should I consider when choosing a doctor-prescribed weight loss medication?

Choosing the right weight loss medication requires careful consideration of your health profile, which includes factors like your BMI, existing medical conditions, and personal weight loss goals. The best approach is to consult a doctor who can recommend an option that suits your specific needs.

When making a decision, think about aspects such as how well the medication works, its safety record, possible side effects, and whether you prefer oral tablets or injectable treatments. A healthcare professional can help you navigate these options to find a solution that fits your lifestyle and supports your overall health.

What serious side effects should I watch out for when using these weight loss medications?

While medications prescribed by doctors for weight loss are generally considered safe when taken as directed, there are potential side effects to keep in mind. Common issues include nausea, vomiting, and digestive discomfort. More serious concerns, though less common, may involve pancreatitis, gallbladder problems, or even rare allergic reactions. For individuals with diabetes, there’s also a possibility of experiencing low blood sugar levels.

Before starting any weight loss medication, it’s crucial to share your full medical history and any existing health conditions with your doctor. Regular check-ups can help identify side effects early and ensure the treatment is both safe and suitable for your needs.

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